enhancement of transdermal delivery of ibuprofen using microemulsion vehicle

objective(s):the objective of this study was to find a stable microemulsion vehicle for transdermal delivery of ibuprofen to improve the skin permeability. materials and methods: microemulsion was prepared using different sorts of oils, surfactants and co-surfactants. pseudo-ternary phase diagrams were used to evaluate the microemulsion domain. the effects of oleic acid and surfactant mixture on skin permeation of ibuprofen were evaluated with excised skins. results: the optimum formulation f3 consisting of 6% oleic acid, 30% cremophor rh40/transcutol p (2:1, w/w) and 59% water phase, showed a high permeation rate of 42.98 μg/cm2/hr. the mean droplet size of microemulsion was about 43 nm and no skin irritation signs were observed on the skin of rabbits. conclusion: these results indicated that this novel microemulsion is a useful formulation for the transdermal delivery of ibuprofen.